ヒアルロン酸ナトリウム 化学特征,用处語,生産方式
外観
红色からうすい黄色、結晶性粉末~粉末又は顆粒
定義
本品は、ヒアルロン酸(*)のナトリウム塩である。参照表现称号:ヒアルロン酸
消融性
水溶状:試験適合水に溶ける。
化粧品の成份用处
皮膚コンディショニング剤
化学的特征
The PhEur 6.3 describes sodium hyaluronate as the sodium salt of
hyaluronic acid, a glycosaminoglycan consisting of D-glucuronic
acid and N-acetyl-D-glucosamine disaccharide units.
Sodium hyaluronate occurs as white to off-white powder or
granules. It is very hygroscopic.
利用
sodium hyaluronate is used as a humectant to increase moisture in the skin, it may also serve as an emulsifier. Sodium hyaluronate is capable of binding 1,800 times its own weight in water. It is the sodium salt of hyaluronic acid and is the most commonly used form.
主な応用
Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. Sodium hyaluronate is widely used as follows:
antifungal agent.
prevents thromboembolic complications.
aldosterone antagonist used as an adjunct in the management of chronic heart failure.
suitable as substrate for hyaluronidase.
Surgical aid (ophthalmological).
定義
Sodium Hyaluronate is a polysaccharide of linear and repeating structural units of the disaccharide D-glucuronic acid and N-acetylD-glucosamine. Hyaluronic acid in human body usually present as polymers with several million molecular weight, and the structural difference by the animal species has not been confirmed.
調製方式
Sodium hyaluronate occurs naturally in vitreous humor, serum,
chicken combs, shark skin, and whale cartilage; it is usually
extracted and purified from chicken combs. It may also be
manufactured by fermentation of selected Streptococcus zooepidemicus
bacterial strains; sodium hyaluronate is removed from the
fermentation medium by filtration and purified by ultrafiltration. It
is then precipitated with an organic solvent and dried.
応用例(製薬)
Sodium hyaluronate is the predominant form of hyaluronic acid at
physiological pH. The name hyaluronan is used when the
polysaccharide is mentioned in general terms, and in the literature
the terms hyaluronic acid and sodium hyaluronate are used
interchangeably.
Hyaluronan is used therapeutically to treat osteoarthritis in the
knee, and is an effective treatment for arthritic pain. Crosslinked
hyaluronan gels are used as drug delivery systems.
Hyaluronan is the most common negatively charged glycosaminoglycan
in the human vitreous humor, and is known to interact
with polymeric and liposomal DNA complexes, where hyaluronan
solutions have been shown to decrease the cellular uptake of
complexes.(4) This is useful for enhancing the availability and
retention time of drugs administered to the eye. It is immunoneutral,
which makes it useful for the attachment of biomaterials for use in
tissue engineering and drug delivery systems; it also has important
applications in the fields of vascosurgery and vascosupplementation.
宁静性
Sodium hyaluronate is used in cosmetics and in topical, parenteral,
and ophthalmic pharmaceutical formulations. It is generally
regarded as a relatively nontoxic and nonirritant material. Sodium
hyaluronate has been reported to be an experimental teratogen.
LD50 (mouse, IP): 1.5 g/kg
LD50 (rabbit, IP): 1.82 g/kg
LD50 (rat, IP): 1.77 g/kg
貯蔵
Sodium hyaluronate should be stored in a cool, dry place in tightly
sealed containers. The powder is stable for 3 years if stored in
unopened containers.
規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (topical gel
preparation).
ヒアルロン酸ナトリウム 下贱と下贱の製品情報
原资料
準備製品